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HRCA/Harvard Research Nursing Home (RNH) National Institute on Aging
(09/30/83 orig. start) 09/15/04-06/30/10
Lewis A. Lipsitz, M.D., Principal Investigator
Summary:
A Multidisciplinary collaboration of investigators from multiple academic institutions in Boston that share the common goal of conducting high-quality clinical research focused on prevalent, disabling, previously neglected syndromes that threaten the independence and quality of life of elderly people.
Download Mobilize Boston Procedure Manual
Download Mobilize Boston Data Codebook
The MOBILIZE Boston Study
Nonlinear Dynamics of Frailty in Aging
NIH 2006-2014
Principal Investigator: Lewis Lipsitz, MD
Summary:
The Aims of this project are 1) To determine cross-sectionally in a representative population of elderly people aged 70 years and over, whether there is a relationship between "frailty" and loss of complexity in the dynamics of multiple physiologic systems. 2) To determine whether a loss of complexity in cardiovascular, cerebrovascular, and/or balance dynamics, is associated with an impaired ability to adapt to common physiologic stresses imposed on these systems. 3) To determine longitudinally over a two-year follow-up period in the same population, whether reduced complexity in the dynamics of these physiologic systems at baseline, or loss of complexity in these systems over time, is predictive of the subsequent development of frailty, its component symptoms, and/or other measures of physical and cognitive functional decline.
Related Publications:
Lipsitz LA. Dynamic models for the study of frailty. Mech Ageing Dev 2008, 129: 675-676.
Collage: The Art and Science of Aging
11/06/03 - open
John N. Morris, Ph.D., Principal Investigator
Summary:
Collage is a group of pioneering organizations - including Hebrew Senior Life, Kendal Outreach, LLC (an affiliate of The Kendal Corporation), and not-for-profit continuing care retirement communities - collaborating with an internationally recognized organization of health services researchers (interRAI) to design, test, and implement a suite of assessment instruments and programs designed to optimize the physical, mental, and social well-being of older adults. Collage is forming a consortium of not-for-profit continuing care retirement communities (CCRCs) to participate in this process. Members will assist with testing and refining the assessment tools, receive reports that will enable them to track outcomes and improve care for residents, implement evidence based programs for their residents, and contribute data to a national database for the purpose of research.
Results of this project have the potential to enhance the lives of millions of older adults living in a variety of settings. The Consortium will be formed in stages over the next three years to include 100 members and serve more than 30,000 individual older adults during the initial phase.
Risk Factors of Age Related Bone Loss
9/1/02 - 08/31/12
Douglas P. Kiel, M.D., Principal Investigator
National Institutes of Health
Summary:
The aims of this grant are to examine the association between lower extremity lean mass and total lean mass, previously measured by dual x-ray absorptiometry (DXA) and the risk for hip and non-vertebral fracture. The second aim is to perform genome-wide association studies (GWAS) using 3529 subjects from the Offspring and Gen3 Cohorts of the Framingham Study who will have genotyping data and QCT measures of BMD and then in 3,000 Original and Offspring Cohort members with DXA BMD. Replication will be performed in multiple other cohort studies. The final aim will be to investigate the interaction of SNPs in four genes related to age-associated accumulation of marrow fat and osteoblast dysfunction with dietary fat intake on vTBMD, and the interaction of four genes related to methylation pathways with plasma folate, vitamin B12 and B6 levels on vTBMD.
Tai Chi for Orthopedic Women: a Pilot Randomized Controlled Trial
12/01/06-08/31/09
Douglas P. Kiel, MD, MPH
This is a randomized, controlled, clinical trial of Tai Chi and its effect on biochemical markers of bone turnover and balance and gait.
Low Magnitude Mechanical Stimulation to Improve BMD
09/01/06-06/30/10
NIH/NIA
Douglas P. Kiel, MD, MPH
Summary:
This is a randomized, double-blind, placebo-controlled trial of low magnitude mechanical simulation with whole body vibration to improve bone mineral density as measured by QCT of the hip and spine and to determine the effect of the intervention on biochemical markers of bone turnover in seniors treated with 10 minutes per day of whole body vibration (0.3g, 30 Hz).
Foot Disorders, Pain and Physical Disability in Elders
05/01/02 - 08/31/09
Marian T. Hannan, D.Sc., Principal Investigator
National Institutes of Health
Summary:
To examine the effect of foot disorders and pain on mobility in the population based Framingham Study. Specifically, to establish the prevalence of foot disorders and foot pain in men and women across a wide age spectrum; to examine whether foot disorders and foot pain are related to lower extremity mobility limitations, and to evaluate whether foot disorders are associated with physical disability.
Cascade
09/30/04 - 07/31/09
NIH/National Institute on Aging
Susan L. Mitchell, M.D., Principal Investigator Cascade Grant Supplement
Summary:
The CASCADE study: Choices, Attitudes, and Strategies for Care of Advanced Dementia at the End-of-Life, is a large, prospective cohort study that will follow the clinical course of NH residents with advanced dementia and their families during the end-stages of the disease and during the dying process.
The Adept Study
2006-2010
National Institutes of Health
Susan Mitchell, MD, Principal Investigator
Summary:
The ADEPT study: Estimating Prognosis in Advanced Dementia
The study aims to develop a prognostic tool for in advanced dementia using nationwide Minimum Data Set data and prospectively validate the tool at the bedside of 600 nursing home residents.
The Antihypertensives and Vascular, Endothelial and Cognitive function Trial (AVEC trial)
February 2008 - December 2012
NIA/NIH
Key Personnel: Ihab Hajjar, MD, MS, Principal Investigator Lewis Lipsitz, MD, Meaghan Hart, BSc
Summary:
High blood pressure can affect a person's memory and blood vessel function. The purpose of this study is to compare the effect of treatment of high blood pressure with candesartan (Atacand©), lisinopril or hydrochlorothiazide on blood vessel function and memory, while the person's blood pressure is controlled below 140/90. This is a 3-arm double-blinded study, where particular cerebrovascular and cognitive tests will be administered at the beginning of the randomization and then again after six-months and one-year of controlled treatment. Participants include community dwelling volunteers from the greater Boston area who are over the age of 60 and have hypertension.
For more information or questions about this study please call 617-363-8484.
Pioneers of Change: A Qualitative Study of Successful Implementors of the Hospital Elder Life Program
Retirement Research Foundation, 01/01/08 - 12/31/10
Sharon K. Inouye, MD, MPH
Summary:
The study seeks to examine and understand the processes that enabled 20-25 successful HELP sites to create system change at their institutions, and to sustain the change amidst challenges.
Rubin FH, Williams JT, Lescisin DA, Mook WJ, Hassan S, Inouye SK. Replicating the Hospital Elder Life Program (HELP) in a community hospital and demonstrating effectiveness using administrative data. J Am Geriatr Soc. 2006;54:969-974.
http://elderlife.med.yale.edu
Impact of Hospitalization in Alzheimer's Disease: Risk Factors and Outcomes
The Alzheimer's Association, 07/01/08-06-30/11
Sharon K. Inouye, MD, MPH
Summary:
The purpose of this study is to examine the frequency, risk factors, and outcomes of hospitalization of participants enrolled in the Massachusetts Alzheimer's Disease Research Center cohort.
Related Publications:
Fong TG, Jones RN, Shi P, Marcantonio ER, Yap L, Rudolph JL, Yang FM, Kiely DK, Inouye SK. Delirium accelerates cognitive decline in Alzheimer's disease. Neurology. 2009;72:1570-1575
Does Namenda Decrease the Incidence and Impact of Delirium on the Cognitive Trajectory in Alzheimer's Disease
Forest Research Institute, 06/01/08 - 11/30/09
Sharon K. Inouye, MD, MPH
Summary:
The purpose of this study is to examine whether Namenda (memantine) results in a decreased incidence of delirium in a cohort of patients with AD and to evaluate whether Namenda (memantine) influences the negative impact of delirium on the short-term cognitive trajectory in AD.
The 3D Study: Deriving & Validating a 3-minute Diagnostic Assessment for Delirium
NIH/National Institute on Aging, 07/01/08-06/30/12
Principal Investigator - Edward R. Marcantonio, MD, SM
Summary:
The goal of this project is to propose, develop, refine, and validate the 3D-CAM: a 3 minute diagnostic assessment for delirium using the CAM algorithm. Dr. Inouye is co-investigator.
Publications:
Inouye SK, Van Dyck CH, Alessi CA, Balkin S, Siegal AP, Horwitz RI. Clarifying confusion: The Confusion Assessment Method. A new method for detection of delirium. Ann Intern Med. 1990; 113: 941 948.Inouye SK, Leo-Summers L, Zhang Y, Bogardus ST, Leslie DL, Agostini JV. A chart-based method for identification of delirium: Validation compared with interviewer ratings using the Confusion Assessment Method. J Am Geriatr Soc. 2005;53:312-318.Wei LA, Fearing MA, Sternberg E, Inouye SK. The Confusion Assessment Method (CAM): A systematic review of current usage. J Am Geriatr Soc. 2008;56:823-830.
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